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Title: Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand
Authors: Michael G. Hudgens
Ira M. Longini
Suphak Vanichseni
Dale J. Hu
Dwip Kitayaporn
Philip A. Mock
M. Elizabeth Halloran
Glen A. Satten
Kachit Choopanya
Timothy D. Mastro
Rollins School of Public Health
Fred Hutchinson Cancer Research Center
Bangkok Metropolitan Administration
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
Mahidol University
HIV/AIDS Collaboration
Keywords: Medicine
Issue Date: 15-Jan-2002
Citation: American Journal of Epidemiology. Vol.155, No.2 (2002), 159-168
Abstract: The Bangkok (Thailand) Metropolitan Administration cohort of injecting drug users (IDUs) consisted of 1,209 IDUs initially seronegative for human immunodeficiency virus (HIV) who were followed from 1995 to 1998 at 15 Administration drug treatment clinics. At enrollment and approximately every 4 months thereafter, participants were assessed for HIV seropositivity. As of December 1998, there were 133 HIV type 1 seroconversions and approximately 2,300 person-years of follow-up. Of the 133 observed seroconversions, specimens from 126 persons were available for subtyping (27 subtype B, 99 subtype E). In this analysis, the authors assessed differences in subtype-specific transmission while controlling for important risk factors. The methodology used accounts for left truncation, interval censoring, and competing risks as well as for time-varying covariates such as each IDU's history of reported frequency of injection and of incarceration. Using plausible epidemiologic assumptions and controlling for behavioral risks, the authors found that a significantly higher transmission probability was associated with subtype E compared with subtype B in this population. Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype.
ISSN: 00029262
Appears in Collections:Scopus 2001-2005

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