Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Evaluation of the acute and subacute toxicity of a choleretic phloracetophenone in experimental animals
Authors: Pawinee Piyachaturawat
Chatsuda Tubtim
Aporn Chuncharunee
Prayad Komaratat
Apichart Suksamrarn
Mahidol University
Ramkhamhaeng University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 24-Mar-2002
Citation: Toxicology Letters. Vol.129, No.1-2 (2002), 123-132
Abstract: Toxicity of a choleretic compound, phloracetophenone (2,4,6-trihydroxyacetophenone; THA) was investigated in mice, rats and hamsters. Acute toxicity of THA was observed to be dependent on species and route of administration, but not sex and age. LD50values for an acute toxicity of a single i.p. administration to adult male hamsters and mice were 338 and 365 mg/kg BW, respectively. It was significantly increased to 489 mg/kg BW in adult male rats and greatly increased by i.g. route. Subacute toxicity was investigated in adult male mice by giving THA at a doses of 37-300 mg/kg BW/day, i.g. for 30 consecutive days. High doses of THA induced periportal hepatocyte degeneration whereas plasma concentrations of alanine and aspartate aminotransferases, bilirubin, and blood urea nitrogen, and hepatic triglyceride content were only slightly increased. The possible therapeutic effect of the choleretic THA was evaluated in the ethinylestradiol (EE)-induced cholestasis. THA enhanced the hepatic clearance of sulfobromophthalein and decreased the elevated plasma alkaline phosphatase in EE-cholestatic rats to control levels. These results suggested that THA at biologically active choleretic dose had low toxicity, it might be safe for further development as a therapeutic agent for a short period of treatment in cholestasis. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
ISSN: 03784274
Appears in Collections:Scopus 2001-2005

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.