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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20610
Title: Anti-HIV-1 Protostane Triterpenes and Digeranylbenzophenone from Trunk Bark and Stems of Garcinia speciosa
Authors: Vatcharin Rukachaisirikul
Phanruethai Pailee
Assdhawut Hiranrat
Patoomratana Tuchinda
Chalobon Yoosook
Jittra Kasisit
Walter C. Taylor
Vichai Reutrakul
Faculty of Science
Mahidol University
The University of Sydney
Keywords: Agricultural and Biological Sciences;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-2003
Citation: Planta Medica. Vol.69, No.12 (2003), 1141-1146
Abstract: Three new protostanes, garciosaterpenes A (1), B (2) and C (3), together with a new digeranylbenzophenone, garciosaphenone A (4) were isolated from the ethyl acetate fractions obtained from the crude methanol extracts of the trunk bark and stems of Garcinia speciosa. The structures were elucidated by spectroscopic methods and chemical reactions. Compounds 1 and 3 showed significant inhibitory activities (IC50 15.5 and 12.2 μg/ mL, respectively) against HIV-1 reverse transcriptase and in the syncytium assay (EC50 5.8 μg/mL with T1 3.4 and 37.0 μg/mL with TI 1.9, respectively). Compound 4 was active in HIV-1 RT assay (IC50 23.9 μg/mL), but toxic in the syncytium assay. This work represents the first report on the anti-HIV-1 activities of the protostane triterpenes.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1242284435&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20610
ISSN: 00320943
Appears in Collections:Scopus 2001-2005

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