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Title: Cytotoxic Coumarins from Mammea harmandii
Authors: Vichai Reutrakul
Pornsiri Leewanich
Patoomratana Tuchinda
Manat Pohmakotr
Thaworn Jaipetch
Samaisukh Sophasan
Thawatchai Santisuk
Mahidol University
Thailand Royal Forest Department
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Nov-2003
Citation: Planta Medica. Vol.69, No.11 (2003), 1048-1051
Abstract: Two new naturally occurring coumarins, isomesuol (1) and mammearin A (2), together with nine known Mammea coumarins 3-11 were isolated from the EtOAc extract of the leaves and twigs of Mammea harmandii. Coumarins 1, 3 and 4 showed cytotoxicity against a panel of mammalian cancer cell lines. Their structures were determined by spectroscopic methods. The assignments of13C-NMR signals of isomesuol (1), which was isolated for the first time as a natural product, have been revised.
ISSN: 00320943
Appears in Collections:Scopus 2001-2005

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