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|Title:||Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process|
University of Leeds
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Tetrahedron Letters. Vol.44, No.40 (2003), 7441-7443|
|Abstract:||A novel palladium-catalysed three component cascade process is described involving carbonylation of an aryl iodide to generate an acyl palladium species which is intercepted by a primary aliphatic/aromatic amine, amide or sulfonamide followed by intramolecular Michael addition to afford 3-substituted isoindolin-1-ones in good yield. © 2003 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Scopus 2001-2005|
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