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Title: Synthesis of 3-substituted isoindolin-1-ones via a palladium-catalysed 3-component carbonylation/amination/Michael addition process
Authors: Xinjie Gai
Ronald Grigg
Tossapol Khamnaen
Shuleewan Rajviroongit
Visuvanathar Sridharan
Lixin Zhang
Simon Collard
Ann Keep
University of Leeds
Mahidol University
Johnson Matthey
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 29-Sep-2003
Citation: Tetrahedron Letters. Vol.44, No.40 (2003), 7441-7443
Abstract: A novel palladium-catalysed three component cascade process is described involving carbonylation of an aryl iodide to generate an acyl palladium species which is intercepted by a primary aliphatic/aromatic amine, amide or sulfonamide followed by intramolecular Michael addition to afford 3-substituted isoindolin-1-ones in good yield. © 2003 Elsevier Ltd. All rights reserved.
ISSN: 00404039
Appears in Collections:Scopus 2001-2005

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