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Title: Mutational analysis of ras gene family in lung cancer in Thai
Authors: Songsak Petmitr
Duangdao Wongsommart
Panee Chaksangchaichot
Tanett Pakeetoot
Pantap Sutinont
Patay Sirivaidyapong
Anant Karalak
Mahidol University
National Cancer Institute Thailand
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Sep-2003
Citation: Oncology Reports. Vol.10, No.5 (2003), 1497-1501
Abstract: H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons 57 and 62 were seen in one patient, whilst no H-ras mutation was found in these patients. Bases change in K-ras gene were G→T transversion (62%), G→A transition (15%) and G→C transition (15%), whereas T→G transversion and A→G transition were detected in N-ras mutant gene.
ISSN: 17912431
Appears in Collections:Scopus 2001-2005

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