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|Title:||Mutational analysis of ras gene family in lung cancer in Thai|
National Cancer Institute Thailand
|Keywords:||Biochemistry, Genetics and Molecular Biology|
|Citation:||Oncology Reports. Vol.10, No.5 (2003), 1497-1501|
|Abstract:||H-, K- and N-ras gene mutations were analyzed in lung cancer from Thai patients. Thirteen out of 58 cases (22%) harbored the mutations. Ten cases showed K-ras gene mutations at codon 12, 1 case presented a mutation at codon 13 and another case exhibited a mutation at codon 63. Silent mutations of N-ras gene in codons 57 and 62 were seen in one patient, whilst no H-ras mutation was found in these patients. Bases change in K-ras gene were G→T transversion (62%), G→A transition (15%) and G→C transition (15%), whereas T→G transversion and A→G transition were detected in N-ras mutant gene.|
|Appears in Collections:||Scopus 2001-2005|
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