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|Title:||Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre|
Peter J. Houghton
King's College London
Prince of Songkla University
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry|
|Citation:||Organic Letters. Vol.5, No.16 (2003), 2879-2882|
|Abstract:||(Matrix presented) Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.|
|Appears in Collections:||Scopus 2001-2005|
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