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Title: Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre
Authors: Arunporn Itharat
Anuchit Plubrukarn
Palangpon Kongsaeree
Tam Bui
Niwat Keawpradub
Peter J. Houghton
King's College London
Prince of Songkla University
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 7-Aug-2003
Citation: Organic Letters. Vol.5, No.16 (2003), 2879-2882
Abstract: (Matrix presented) Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.
ISSN: 15237060
Appears in Collections:Scopus 2001-2005

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