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Title: Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
Authors: Juthathip Mongkolsapaya
Wanwisa Dejnirattisai
Xiao Ning Xu
Sirijitt Vasanawathana
Nattaya Tangthawornchaikul
Aroonrung Chairunsri
Siraporn Sawasdivorn
Thaneeya Duangchinda
Tao Dong
Sarah Rowland-Jones
Pa Thai Yenchitsomanus
Andrew McMichael
Prida Malasit
Gavin Screaton
John Radcliffe Hospital
Mahidol University
Khon Kaen Regional Hospital
Thailand National Center for Genetic Engineering and Biotechnology
Queen Sirikit National Institute of Child Health
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jul-2003
Citation: Nature Medicine. Vol.9, No.7 (2003), 921-927
Abstract: Dengue virus presents a growing threat to public health in the developing world. Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (DHF), the more serious manifestation of the disease, occurs more frequently upon reinfection with a second serotype. We have studied dengue virus-specific T-cell responses in Thai children. During acute infection, few dengue-responsive CD8+T cells were recovered; most of those present showed an activated phenotype and were undergoing programmed cell death. Many dengue-specific T cells were of low affinity for the infecting virus and showed higher affinity for other, probably previously encountered strains. Profound T-cell activation and death may contribute to the systemic disturbances leading to DHF, and original antigenic sin in the T-cell responses may suppress or delay viral elimination, leading to higher viral loads and increased immunopathology.
ISSN: 10788956
Appears in Collections:Scopus 2001-2005

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