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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20716
Title: Levels of macrophage inflammatory protein 1α-(MIP-1α) and MIP-1β in intervillous blood plasma samples from women with placental malaria and human immunodeficiency virus infection
Authors: Sujittra Chaisavaneeyakorn
Julie M. Moore
Lisa Mirel
Caroline Othoro
Juliana Otieno
Sansanee C. Chaiyaroj
Ya Ping Shi
Bernard L. Nahlen
Altaf A. Lal
Venkatachalam Udhayakumar
National Center for Infectious Diseases
The University of Georgia
Mahidol University
Kenya Medical Research Institute
New Nyanza Provincial General Hospital
Organisation Mondiale de la Sante
Centers for Disease Control and Prevention
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jul-2003
Citation: Clinical and Diagnostic Laboratory Immunology. Vol.10, No.4 (2003), 631-636
Abstract: Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β play an important role in modulating immune responses. To understand their importance in immunity to placental malaria (PM) and in human immunodeficiency virus (HIV)-PM coinfection, we investigated levels of these chemokines in the placental intervillous blood plasma (IVB plasma) and cord blood plasma of HIV-negative PM-negative, HIV-negative PM-positive, HIV-positive PM-negative, and HIV-positive PM-positive women. Compared to HIV-negative PM-negative women, the MIP-1β concentration in IVB plasma was significantly elevated in HIV-negative PM-positive women and HIV-positive PM-positive women, but it was unaltered in HIV-positive PM-negative women. Also, PM-infected women, irrespective of their HIV status, had significantly higher levels of MIP-1β than HIV-positive PM-negative women. The MIP-1α level was not altered in association with either infection. The IVB plasma levels of MIP-1α and MIP-1β positively correlated with the cord blood plasma levels of these chemokines. As with IVB plasma, only cord plasma from PM-infected mothers had significantly elevated levels of MIP-1β compared to PM-negative mothers, irrespective of their HIV infection status. MIP-1β and MIP-1α levels in PM-positive women were positively associated with parasite density and malaria pigment levels. Regardless of HIV serostatus, the IVB MIP-1β level was significantly lower in women with PM-associated anemia. In summary, an elevated level of MIP-1β was associated with PM. HIV infection did not significantly alter these two chemokine levels in IVB plasma.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=12444294421&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20716
ISSN: 1071412X
Appears in Collections:Scopus 2001-2005

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