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Title: A bioactive triterpenoid and vulpinic acid derivatives from the mushroom Scleroderma citrinum
Authors: Somdej Kanokmedhakul
Kwanjai Kanokmedhakul
Thirada Prajuabsuk
Kasem Soytong
Palangpon Kongsaeree
Apichart Suksamrarn
Khon Kaen University
King Mongkut's Institute of Technology Ladkrabang
Mahidol University
Ramkhamhaeng University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2003
Citation: Planta Medica. Vol.69, No.6 (2003), 568-571
Abstract: A new lanostane-type triterpenoid, (20S,22S,23E)-22-O-acetyl-25-hydroxylanosta-8,23(E)-dien-3-one (1), isolated as a new natural product for the first time, methyl 4,4′-dimethoxyvulpinate (2), together with the known compound 4,4′-dimethoxyvulpinic acid (3) were isolated from the mushroom Scleroderma citrinum. Their structures were determined using spectroscopic and chemical methods, and an X-ray analysis was performed to confirm structure of 1. Compound 1 exhibited significant antiviral activity against Herpes simplex type 1. Compound 3 and two of its derivatives, the dibromo derivative 5 and acetate derivative 6, exhibited activity towards Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the NCI-H187 cell line.
ISSN: 00320943
Appears in Collections:Scopus 2001-2005

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