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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20724
Title: Relationship between plasma interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western Kenya
Authors: Sujittra Chaisavaneeyakorn
Caroline Othoro
Ya Ping Shi
Juliana Otieno
Sansanee C. Chaiyaroj
Altaf A. Lal
Venkatachalam Udhayakumar
National Center for Infectious Diseases
Mahidol University
Kenya Medical Research Institute
New Nyanza Provincial General Hospital
Centers for Disease Control and Prevention
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jun-2003
Citation: Clinical and Diagnostic Laboratory Immunology. Vol.10, No.3 (2003), 362-366
Abstract: In this study, we investigated whether levels of interleukin-12 (IL-12) and IL-18 in plasma are associated with severe malarial anemia outcomes in an area of holoendemicity in western Kenya. We compared plasma IL-12 and IL-18 levels in six groups of children grouped into the categories aparasitemic, asymptomatic, mild malaria, high-density uncomplicated malaria (UC), moderate malarial anemia (MMA), or severe malarial anemia (SMA). IL-12 levels were significantly reduced in children with SMA (P < 0.05) but not in other groups compared to children in the aparasitemic control group. IL-18, a cytokine known to be critical for the induction of gamma interferon along with IL-12, was produced more frequently (70%) in children with UC (P = 0.06) than in children in the aparasitemic control group (32%). However, in the SMA group the IL-18 response rate declined to 30%, which was similar to that in the aparasitemic control group, which showed a 32% response rate. This finding suggests that the IL-18 response may be impaired in children with SMA. In summary, the results from this study support the hypothesis that impairment of IL-12 and/or IL-18 response may contribute to the development of severe malarial anemia in areas of holoendemicity for malaria.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0038633500&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20724
ISSN: 1071412X
Appears in Collections:Scopus 2001-2005

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