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Title: Manganese-based complexes of radical scavengers as neuroprotective agents
Authors: Opa Vajragupta
Preecha Boonchoong
Yaowared Sumanont
Hiroshi Watanabe
Yuvadee Wongkrajang
Naparat Kammasud
Mahidol University
University of Toyama
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-May-2003
Citation: Bioorganic and Medicinal Chemistry. Vol.11, No.10 (2003), 2329-2337
Abstract: Manganese was incorporated in the structure of the selected antioxidants to mimic the superoxide dismutase (SOD) and to increase radical scavenging ability. Five manganese complexes (1-5) showed potent SOD activity in vitro with IC50of 1.18-1.84 μM and action against lipid peroxidation in vitro with IC50of 1.97-8.00 μM greater than their ligands and trolox. The manganese complexes were initially tested in vivo at 50 mg/kg for antagonistic activity on methamphetamine (MAP)-induced hypermotility resulting from dopamine release in the mice brain. Only manganese complexes of kojic acid (1) and 7-hydroxyflavone (3) exhibited the significant suppressions on MAP-induced hypermotility and did not significantly decrease the locomotor activity in normal condition. Manganese complex 3 also showed protective effects against learning and memory impairment in transient cerebral ischemic mice. These results supported the brain delivery and the role of manganese in SOD activity as well as in the modulation of brain neurotransmitters in the aberrant condition. Manganese complex 3 from 7-hydroxyflavone was the promising candidate for radical implicated neurodegenerative diseases. © 2003 Elsevier Science Ltd. All rights reserved.
ISSN: 09680896
Appears in Collections:Scopus 2001-2005

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