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dc.contributor.authorOpa Vajraguptaen_US
dc.contributor.authorPreecha Boonchoongen_US
dc.contributor.authorYaowared Sumanonten_US
dc.contributor.authorHiroshi Watanabeen_US
dc.contributor.authorYuvadee Wongkrajangen_US
dc.contributor.authorNaparat Kammasuden_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Toyamaen_US
dc.identifier.citationBioorganic and Medicinal Chemistry. Vol.11, No.10 (2003), 2329-2337en_US
dc.description.abstractManganese was incorporated in the structure of the selected antioxidants to mimic the superoxide dismutase (SOD) and to increase radical scavenging ability. Five manganese complexes (1-5) showed potent SOD activity in vitro with IC50of 1.18-1.84 μM and action against lipid peroxidation in vitro with IC50of 1.97-8.00 μM greater than their ligands and trolox. The manganese complexes were initially tested in vivo at 50 mg/kg for antagonistic activity on methamphetamine (MAP)-induced hypermotility resulting from dopamine release in the mice brain. Only manganese complexes of kojic acid (1) and 7-hydroxyflavone (3) exhibited the significant suppressions on MAP-induced hypermotility and did not significantly decrease the locomotor activity in normal condition. Manganese complex 3 also showed protective effects against learning and memory impairment in transient cerebral ischemic mice. These results supported the brain delivery and the role of manganese in SOD activity as well as in the modulation of brain neurotransmitters in the aberrant condition. Manganese complex 3 from 7-hydroxyflavone was the promising candidate for radical implicated neurodegenerative diseases. © 2003 Elsevier Science Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleManganese-based complexes of radical scavengers as neuroprotective agentsen_US
Appears in Collections:Scopus 2001-2005

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