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Title: Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides
Authors: Palangpon Kongsaeree
Samran Prabpai
Nongluksna Sriubolmas
Chanika Vongvein
Suthep Wiyakrutta
Mahidol University
Chulalongkorn University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-May-2003
Citation: Journal of Natural Products. Vol.66, No.5 (2003), 709-711
Abstract: Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.
ISSN: 01633864
Appears in Collections:Scopus 2001-2005

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