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Title: 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
Authors: Veda Prachayasittikul
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
Center of Data Mining and Biomedical Informatics
Department of Clinical Microbiology and Applied Technology
Keywords: Metal binding compound;Antineurodegenerative;Anticancer;Aantidiabetic;Multifunctional actions;Structure–activity relationships;Open Access article
Issue Date: 2013
Citation: Drug Design, Development and Therapy. Vol.7, 2013, 1157-1178
Abstract: Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure–activity relationships.
Appears in Collections:MT-Article

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