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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20757
Title: Co-mutation of HPV16 E6 and E7 genes in Thai squamous cervical carcinomas
Authors: Kulthida Vaeteewoottacharn
Patcharee Jearanaikoon
Mathurose Ponglikitmongkol
Mahidol University
Khon Kaen University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Mar-2003
Citation: Anticancer Research. Vol.23, No.2 C (2003), 1927-1931
Abstract: Infection with high-risk HPV16 is well associated with invasive cervical carcinomas. Variations in the E6 gene of HPV16 are shown to correlate with both the geographical areas and the oncogenicity. Here, we have characterized HPV16 DNA variants in the E6 and E7 coding regions of 31 Thai cervical squamous cell carcinomas. Five groups of E6 variants were identified. A mutation from T to G at nucleotide 178, leading to a change from aspartate to glutamate (D25E), was the most common variation accounting for 70%. Interestingly, 90% of these E6 (D25E) variants coincided with a specific type of E7 mutation, N29S. This is the first finding of coordinated change between E6 (D25E) and E7 (N29S) in HPV, which might indicate a specific variant for the Thai population. These comutations may not only represent an area-specific strain but may also be valuable for studying the virus and developing a suitable vaccine in Thailand.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037862058&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20757
ISSN: 02507005
Appears in Collections:Scopus 2001-2005

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