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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/20858
Title: Behavior of the Dengue Virus in Solution
Authors: Patchima Sithisarn
Lukkana Suksanpaisan
Chutima Thepparit
Duncan R. Smith
Mahidol University
Keywords: Immunology and Microbiology
Issue Date: 1-Dec-2003
Citation: Journal of Medical Virology. Vol.71, No.4 (2003), 532-539
Abstract: The dengue virus consists of four antigenically related but distinct viruses, termed Dengue virus 1-4 (DEN 1-4). We have established that the dengue virus loses infectivity over time in solution in an exponentially declining manner. The four strains examined (one from each serotype) have half-lives that range from 2.5 to 7.5 hr in defined medium. The half-life is temperature and pH-dependent and is affected by the nature of the host cell in which it is produced, but is not dependent upon the presence of either Mg2+ ions or chelating agents. Electron microscopy (EM) of solutions of the dengue virus show almost complete virus aggregation after 24 hr at room temperature, while RT-PCR shows an intact RNA genome. These results show that the solution environment of the dengue virus is an important determinant of dengue virus infectivity. © 2003 Wiley-Liss, Inc.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0142244382&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/20858
ISSN: 01466615
Appears in Collections:Scopus 2001-2005

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