Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Failures of 1 week on, 1 week off antiretroviral therapies in a randomized trial
Authors: Jintanat Ananworanich
Reto Nuesch
Michelle Le Braz
Ploechan Chetchotisakd
Asda Vibhagool
Saijai Wicharuk
Kiat Ruxrungtham
Hansjakob Furrer
David Cooper
Bernard Hirschel
Universitatsspital Basel
Hopitaux universitaires de Geneve
Khon Kaen University
Mahidol University
Chulalongkorn University
UniversitatsSpital Bern
Kirby Institute
Service des Maladies Infectieuses
Keywords: Immunology and Microbiology
Issue Date: 17-Oct-2003
Citation: AIDS. Vol.17, No.15 (2003)
Abstract: Background: Scheduled treatment interruptions are being evaluated in an effort to decrease costs and side effects of highly active antiretroviral therapy (HAART). A schedule of 1 week on and 1 week off therapy offers the promise of 50% less drug exposure with continuously undetectable HIV RNA concentration. Methods: In the Staccato study 600 patients on successful HAART were to be randomized to either continued therapy, CD4-guided therapy, or one week on, one week off therapy. A scheduled preliminary analysis evaluated effectiveness in the 1-week-on-1-week-off arm. Results: Of 36 evaluable patients, 19 (53%) had two successive HIV RNA concentrations > 500 copies/ml at the end of the week off therapy, and were classified as virological failure. Most of those who failed took didanosine, stavudine, saquinavir, and ritonavir (11 patients). In these patients, there was no evidence of mutations suggestive of drug resistance, and plasma saquinavir levels were within the expected range. Two of three patients failing on triple nucleotides had drug resistance mutations, but nonetheless responded to reintroduction of triple nucleotide therapy. One of two patients taking nevirapine, and one of eight taking efavirenz, also failed. Both had resistance mutations at the time of failure, but not at baseline. Conclusions: The 1-week-on-1-week-off schedule, as tested in the Staccato study, showed an unacceptably high failure rate and was therefore terminated. © 2003 Lippincott Williams & Wilkins.
ISSN: 02699370
Appears in Collections:Scopus 2001-2005

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.