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dc.contributor.authorKruavon Balachandraen_US
dc.contributor.authorPikul Laisupasinen_US
dc.contributor.authorPanadda Dhepaksonen_US
dc.contributor.authorJiranan Warachiten_US
dc.contributor.authorUdom Jantraraksrien_US
dc.contributor.authorSurapol Issaragrisilen_US
dc.contributor.authorXiang Li Yangen_US
dc.contributor.authorGeng Xi Huen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherInstitute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences Chinese Academy of Sciencesen_US
dc.identifier.citationAsian Pacific Journal of Allergy and Immunology. Vol.21, No.3 (2003), 171-178en_US
dc.description.abstractThis preliminary study aimed to investigate sensitivity and specificity of a protein chip system for multi-tumor marker serodiagnosis of ten types of cancers, and to understand the possible clinical applications of this protein chip for the Thai population. The specific cancers diagnosed by this protein chip are lung, breast, liver, cervix, colo-rectal, stomach, ovary, esophagus, prostate and pancreas cancers. We analyzed 215 serum samples of which 165 were obtained from clinically confirmed cancer patients and 50 from healthy people with no evidence of cancer. The sensitivity and specificity of the protein chip were 82.4% and 94.0%, respectively. The success rate of the protein chip for detecting all 10 types of cancers varied from 57% to 100%. The value of the simultaneous measurement of multiple tumor markers using the protein chip for cancer screening lied in the higher sensitivity compared to using single tumor markers for each type of cancer. In short, protein chips may be useful in mass screening for cancer during health checkups as well as for metastasis follow-up of cancer patients.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePreliminary clinical evaluation of a protein chip for tumor marker serodiagnosis of various cancersen_US
Appears in Collections:Scopus 2001-2005

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