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Title: Human immunodeficiency virus type 1 primary isolate neutralization resistance is associated with the syncytium-inducing phenotype and lower CD4 cell counts in subtype CRF01_AE-infected patients
Authors: Victoria R. Polonis
Mark S. De Souza
Janice M. Darden
Somsak Chantakulkij
Thippawan Chuenchitra
Sorachai Nitayaphan
Arthur E. Brown
Merlin L. Robb
Deborah L. Birx
Armed Forces Research Institute of Medical Sciences, Thailand
Mahidol University
Walter Reed Army Institute of Research
Keywords: Immunology and Microbiology
Issue Date: 1-Aug-2003
Citation: Journal of Virology. Vol.77, No.15 (2003), 8570-8576
Abstract: A number of human immunodeficiency virus type 1 (HIV-1) non-B-subtype products have been developed for present or future vaccine trials; in Thailand, several studies using subtype B and/or CRF01_AE vaccines have been conducted. To better characterize the biologic properties of these subtypes, 70 HIV-1 subtype B and E isolates were phenotyped as syncytium-inducing (SI) or non-syncytium-inducing (NSI) isolates and assessed for sensitivity to neutralizing antibody (NAb). A significantly higher number of NSI subtype E viruses were neutralization sensitive than SI subtype E viruses (P = 0.009), while no association between viral phenotype and sensitivity to NAb was observed for subtype B (P = 0.856), suggesting a difference in the neutralization patterns of subtypes B and E. Strikingly, concurrent CD4 T-cell numbers were significantly lower for subtype E-infected patients whose isolates were more resistant to NAb, both for the overall study group (P < 0.001) as well as for the 22 patients with NSI isolates (P = 0.013). Characterization of the evolution of biologic properties of both B and non-B HIV-1 subtypes will provide a clearer understanding of the repertoire of antibodies that must be elicited for a vaccine to be effective against all phenotypes and subtypes.
ISSN: 0022538X
Appears in Collections:Scopus 2001-2005

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