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Title: Longitudinal study of humoral immune responses in HIV type 1 subtype CRF01_AE (E)-infected Thai patients with different rates of disease progression
Authors: Thippawan Chuenchitra
Victoria R. Polonis
Chantapong Wasi
Suda Louisirirojchanakul
Sorachai Nitayaphan
Ruengpung Sutthent
Josephine H. Cox
Mark S. De Souza
Arthur E. Brown
Deborah L. Birx
Armed Forces Research Institute of Medical Sciences, Thailand
Mahidol University
Walter Reed Army Institute of Research
Keywords: Immunology and Microbiology
Issue Date: 1-Apr-2003
Citation: AIDS Research and Human Retroviruses. Vol.19, No.4 (2003), 293-305
Abstract: Identification of immune correlates associated with disease progression will provide information for HIV-1 vaccine design in countries such as Thailand, where the prevalent subtypes (B and CRF01_AE [E]) are characterized. In this study, plasma viral load and humoral immune responses were measured in 20 HIV-1 subtype E-infected Thai patients with different rates of disease progression, based on CD4+ T cell decline and clinical symptoms. Nine progressors (PRs) and 11 slower progressors (SPs) were evaluated. CD4+ T cell counts were inversely correlated with viral load (p = 0.004) and positively correlated with p24 Ab (p = 0.022). In progressors, p24 Ab showed a significant decrease (p < 0.001) over time. V3 and gp41 Ab did not change significantly in either group. Both CD4-binding site (CD4/gp120BS) and gp120 titers correlated positively with neutralizing antibody (NAb) against both a subtype E cell line-adapted virus (NP03) and a primary isolate (TH023). However, V3 Ab correlated only with NAb against NP03 (p < 0.001). Increased NAb over time was observed more frequently in SPs as compared with PRs, against both the TH023 (p = 0.004) and NPO3 (p= 0.004) viruses. Cross-clade antibody-dependent cellular cytotoxicity was demonstrated in both groups. These data suggest that in HIV-1 subtype E infection, declining p24 Ab titer is a predictive marker of disease progression, as described for subtype B. Furthermore, in subtype E-infected patients, slower progressors retain the immune competence to develop new antibody responses to Env over time; these evolving responses may contribute to prolonged survival during HIV-1 disease progression.
ISSN: 08892229
Appears in Collections:Scopus 2001-2005

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