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Title: The efficacy of combined mefloquine-artesunate versus mefloquine-primaquine on subsequent development of Plasmodium falciparum gametocytemia
Authors: Yupin Suputtamongkol
Supat Chindarat
Saowalak Silpasakorn
Suchada Chaikachonpatd
Kimheng Lim
Kittiporn Chanthapakajee
Naparat Kaewkaukul
Visanu Thamlikitkul
Mahidol University
Saiyok Hospital
Bongtee Health Center
Keywords: Immunology and Microbiology
Issue Date: 1-Jan-2003
Citation: American Journal of Tropical Medicine and Hygiene. Vol.68, No.5 (2003), 620-623
Abstract: An open randomized controlled study of mefloquine-artesunate and mefloquine-primaquine for the treatment of uncomplicated Plasmodium falciparum malaria was carried out in Kanchanaburi in the Saiyok District in western Thailand. Weekly parasite counts from thick and thin blood films were done for six weeks. The gametocyte carriage rate was calculated and compared between the two treatment groups. Gametocytes on presentation, recrudescent infection, and reinfection were the significant factors associated with subsequent development of gametocytemia. It is the increased propensity of recrudescent infections to produce gametocytes that drives drug resistance. The results of this study confirmed that the complete eradication of asexual forms of P. falciparum by effective antimalarial treatment, but not by combination treatment with primaquine, is the most effective means to prevent subsequent gametocytemia.
ISSN: 00029637
Appears in Collections:Scopus 2001-2005

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