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dc.contributor.authorSimon Ogwangen_US
dc.contributor.authorMichael Englen_US
dc.contributor.authorMatthäus Viglen_US
dc.contributor.authorHerwig Kollaritschen_US
dc.contributor.authorGerhard Wiedermannen_US
dc.contributor.authorWalther H. Wernsdorferen_US
dc.contributor.otherLwala Hospitalen_US
dc.contributor.otherUniversitat Wienen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherDept. Specific Prophylaxis/Trop. M.en_US
dc.identifier.citationWiener Klinische Wochenschrift, Supplement. Vol.115, No.3 (2003), 45-49en_US
dc.description.abstractFollowing the WHO protocol for in-vivo tests in areas with intense transmission of uncomplicated falciparum malaria, a randomized comparison of the in-vivo efficacy of chloroquine alone, sulfadoxine/pyrimethamine alone, and their combined administration was carried out in the third quarter of 2001 in Kaberamaido District, northeastern Uganda. Malaria in the study area is hyper-endemic, with a high prevalence of Plasmodium falciparum. The patients were infants and young children with a median age of 15 months. Of the 117 originally enrolled patients, 104 had a complete follow-up with presentation at all scheduled examinations. In the chloroquine group (n = 42), 55% were classified as adequate clinical response, 26% as early treatment failure, and 19% as late clinical failure. In the sulfadoxine/pyrimethamine group (n = 30), the respective figures were 83%, 13% and 3%, and in the group with combined treatment (n = 32), 88%, 6% and 6%. In terms of clinical cure rate, speed of clinical relief and parasite clearance the combined treatment proved to be the most effective of the three drug regimens. In the patients with adequate clinical response, a significant post-therapeutic increase of the haematocrit was observed, which was particularly marked in patients who had also cleared their parasitaemia. Increase of the efficacy of chloroquine with age indicates the early development of semi-immunity in the study area, with conserved efficacy of chloroquine in semi-immune persons.en_US
dc.rightsMahidol Universityen_US
dc.titleClinical and parasitological response of Plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in rural Ugandaen_US
dc.typeConference Paperen_US
Appears in Collections:Scopus 2001-2005

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