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|Title:||Anti-HIV-1 Limonoid: First Isolation from Clausena excavata|
John W. Daly
Thomas F. Spande
National Institute of Diabetes and Digestive and Kidney Diseases
|Keywords:||Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Phytotherapy Research. Vol.17, No.9 (2003), 1101-1103|
|Abstract:||A limonoid, clausenolide-1-ethyl ether (1) and two coumarins, dentatin (2) and nor-dentatin (3), were isolated from Clausena excavata. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV-1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti-HIV-1 substance, (+)-calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti-HIV-1 activity. These compounds, 1-3, did not show any cytotoxic effect against KB and BC-1 cell lines (IC50value > 20 μg/mL). Copyright © 2003 John Wiley & Sons, Ltd.|
|Appears in Collections:||Scopus 2001-2005|
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