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Title: Anti-HIV-1 Limonoid: First Isolation from Clausena excavata
Authors: Arunrat Sunthitikawinsakul
Ngampong Kongkathip
Boonsong Kongkathip
Sida Phonnakhu
John W. Daly
Thomas F. Spande
Yuth Nimit
Chanita Napaswat
Jittra Kasisit
Chalobon Yoosook
Kasetsart University
National Institute of Diabetes and Digestive and Kidney Diseases
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Nov-2003
Citation: Phytotherapy Research. Vol.17, No.9 (2003), 1101-1103
Abstract: A limonoid, clausenolide-1-ethyl ether (1) and two coumarins, dentatin (2) and nor-dentatin (3), were isolated from Clausena excavata. Limonoid 1 was obtained from the crude ethanol extract of the rhizomes and the roots but had not previously been isolated from C. excavata and exhibited HIV-1 inhibitory activity. Coumarins 2 and 3, with their structures related to an anti-HIV-1 substance, (+)-calanolide A (4), were obtained from the crude chloroform extract of the rhizomes. Both induced toxicity to cells used in a syncytium assay for anti-HIV-1 activity. These compounds, 1-3, did not show any cytotoxic effect against KB and BC-1 cell lines (IC50value > 20 μg/mL). Copyright © 2003 John Wiley & Sons, Ltd.
ISSN: 0951418X
Appears in Collections:Scopus 2001-2005

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