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Title: Design of salbutamol EOP tablets from pharmacokinetics parameters
Authors: Nuttanan Sinchaipanid
Sansanee Pongwai
Pichet Limsuwan
Ampol Mitrevej
Mahidol University
Rangsit University
King Mongkuts University of Technology Thonburi
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 19-May-2003
Citation: Pharmaceutical Development and Technology. Vol.8, No.2 (2003), 135-142
Abstract: Salbutamol elementary osmotic pump (EOP) tablets were developed, and fundamental variables affecting their release characteristics were evaluated. The effects of film thickness and compression force on drug release from the tablets containing fixed amount of sodium chloride used as osmogent were evaluated. The core tablets were directly compressed at four compression forces and coated with 3% wt/vol cellulose acetate in acetone to levels of 2%, 3%, and 4% wt/wt. Coated tablets were drilled with CO2laser beam to form drug delivery orifice of ∼400 μm in diameter. The drug release was found to follow zero order fashion. The release rate decreased with the increased film thickness and was not affected by the compression force or porosity. The tablets coated to 3% and 4% levels exhibited the'release rates within the range calculated from pharmacokinetic data. To illustrate the effect of osmogent content, the tablets were prepared at four osmogent levels and compressed at a constant compression force. The core tablets were coated to a level of 3% wt/wt. The release rate was initially increased with osmogent content and then decreased. At higher osmogent contents, the drug fraction in soluble component was decreased and resulted in the reduction of drug release. In conclusion, film thickness and osmogents played important roles in drug release from EOP tablets.
ISSN: 10837450
Appears in Collections:Scopus 2001-2005

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