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Title: Early origin and recent expansion of Plasmodium falciparum
Authors: Deirdre A. Joy
Xiaorong Feng
Jianbing Mu
Tetsuya Furuya
Kesinee Chotivanich
Antoniana U. Krettli
May Ho
Alex Wang
Nicholas J. White
Edward Suh
Peter Beerli
Xin zhuan Su
National Institute of Allergy and Infectious Diseases
Mahidol University
Fundacao Oswaldo Cruz
University of Calgary
NIH Center for Information Technology
Florida State University
Keywords: Multidisciplinary
Issue Date: 11-Apr-2003
Citation: Science. Vol.300, No.5617 (2003), 318-321
Abstract: The emergence of virulent Plasmodium falciparum in Africa within the past 6000 years as a result of a cascade of changes in human behavior and mosquito transmission has recently been hypothesized. Here, we provide genetic evidence for a sudden increase in the African malaria parasite population about 10,000 years ago, followed by migration to other regions on the basis of variation in 100 worldwide mitochondrial DNA sequences. However, both the world and some regional populations appear to be older (50,000 to 100,000 years old), suggesting an earlier wave of migration out of Africa, perhaps during the Pleistocene migration of human beings.
ISSN: 00368075
Appears in Collections:Scopus 2001-2005

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