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Title: Bioactive azafluorenone alkaloids from polyalthia debilis (Pierre) finet and gagnep
Authors: Supaluk Prachayasittikul
Patumporn Manam
Maneekarn Chinworrungsee
Chartchalerm Isarankura-Na-Ayudhya
Somsak Ruchirawat
Virapong Prachayasittikul
Keywords: Polyalthia debilis;azafluorenone;onychine;antimicrobial;antimalarial and cytotoxic activities;Open Access article
Issue Date: 2009
Citation: Molecules. Vol.14, No.11 (2009), 4414-4424
Abstract: This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β–sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
ISSN: 1420-3049
Appears in Collections:MT-Article

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