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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/2112
Title: Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
Authors: Izumi Naka
Nao Nishida
Jintana Patarapotikul
Pornlada Nuchnoi
Katsushi Tokunaga
Hathairad Hananantachai
Naoyuki Tsuchiya
Jun Ohashi
Issue Date: 2009
Publisher: BioMed Central Ltd.
Citation: Malaria Journal. Vol.8, No.1 (2009), 1-6
Abstract: Background: It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria. Methods: A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients). Results: Only rs1881457 located in the promoter region of IL13, which is in linkage disequilibrium with rs1800925 (r2 = 0.73), showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the promoter of IL13, but not the other genes. Conclusion: A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/2112
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