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dc.contributor.authorSupaluk Prachayasittikulen_US
dc.contributor.authorNirun Sornsongkhramen_US
dc.contributor.authorRatchanok Pingaewen_US
dc.contributor.authorApilak Worachartcheewanen_US
dc.contributor.authorSomsak Ruchirawaten_US
dc.contributor.authorVirapong Prachayasittikulen_US
dc.date.accessioned2012-07-24T08:37:55Z-
dc.date.accessioned2017-06-20T16:24:51Z-
dc.date.available2012-07-24T08:37:55Z-
dc.date.available2017-06-20T16:24:51Z-
dc.date.issued2009-
dc.identifier.citationMolecules. Vol.14, No.8 (2009), 2768-2779en_US
dc.identifier.issn1420-3049-
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/2113-
dc.description.abstractThis study reports the synthesis of some substituted 5-iodouracils and their bioactivities. Alkylation of 5-iodouracils gave predominately N1-substituted-(R)-5- iodouracil compounds 7a-d (R = n-C4H9, s-C4H9, CH2C6H11, CH2C6H5) together with N1,N3-disubstituted (R) analogs 8a-b (R = n-C4H9, CH2C6H11). Their antimicrobial activity was tested against 27 strains of microorganisms using the agar dilution method. The analogs 7a, 7c and 7d displayed 25-50% inhibition against Branhamella catarrhalis, Neisseria mucosa and Streptococcus pyogenes at 0.128 mg/mL. No antimalarial activity was detected for any of the analogs when tested against Plasmodium falciparum (T9.94). Their anticancer activity was also examined. Cyclohexylmethyl analogs 7c and 8b inhibited the growth of HepG2 cells. Significantly, N1,N3-dicyclohexylmethyl analog 8b displayed the most potent anticancer activity, with an IC50 of 16.5 g/mL. These 5- iodouracil analogs represent a new group of anticancer and antibacterial agents with potential for development for medicinal applications.en_US
dc.language.isoen_USen_US
dc.subject5-iodouracil analogsen_US
dc.subjectN-alkylationen_US
dc.subjectantibacterialen_US
dc.subjectantimalarialen_US
dc.subjectanticancer activitiesen_US
dc.subjectOpen Access articleen_US
dc.titleSynthesis of N-Substituted 5-Iodouracils as antimicrobial and anticancer agentsen_US
dc.typeArticleen_US
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