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dc.contributor.authorKulkanya Chokephaibulkiten_US
dc.contributor.authorWanatpreeya Phongsamarten_US
dc.contributor.authorNirun Vanpraparen_US
dc.contributor.authorTawee Chotpitayasunondhen_US
dc.contributor.authorSanay Chearskulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherQueen Sirikit National Institute of Child Healthen_US
dc.identifier.citationVaccine. Vol.22, No.15-16 (2004), 2018-2022en_US
dc.description.abstractAlthough most of Thai children older than 2 years are immune against Haemophilus influenzae type b (Hib) without prior vaccination, it may not be the case in HIV-infected children. Of 44 HIV-infected children tested before vaccination at the mean age of 36 months (range 24-84 months), 32 (73%) were susceptible (anti-PRP <0.15 μg/ml). At 6 months after a single dose of tetanus-conjugated Hib vaccination, 67% developed anti-PRP ≥0.15 μg/ml, however, only 33% developed titer of ≥1 μg/ml. Four of seven (57%) with anti-PRP 0.15-0.99 μg/ml at baseline were boosted to the titer of ≥1 μg/ml after vaccination. Seroconversion rate and geometric mean titer (GMT) level in response to the vaccination did not correlate with HIV stage, but did correlate with viral load level of 100,000 copies/ml. HIV-infected children older than 2 years would benefit from Hib vaccination, although, one dose catch-up schedule is not sufficient in a third of these children. A second dose is needed in these children especially those with viral load of level of >100,000 copies/ml. © 2003 Elsevier Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleCatch-up vaccination against Haemophilus influenzae type b in human immunodeficiency virus-infected Thai children older than 2 years olden_US
Appears in Collections:Scopus 2001-2005

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