Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/2119
Title: Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activities of Eclipta prostrata Linn
Authors: Rungrot Cherdtrakulkiat
Somchai Boonpangrak
Somsak Ruchirawat
Ratchanok Pingaew
Virapong Prachayasittikul
Supaluk Prachayasittikul
Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology
Mahidol University. Faculty of Medical Technology. Center for Innovation Development and Technology Transfer
Mahidol University. Faculty of Medical Technology. Center of Data Mining and Biomedical Informatics
Keywords: Eclipta prostrata,;Compositae;Bioactive triterpenoids;Antimicrobials;Antioxidants;Cytotoxic activity;Open Access article
Issue Date: Mar-2015
Citation: Journal of Applied Pharmaceutical Science. Vol.5, No.3 (2015), 46-50
Abstract: Bioactive triterpenoids; 3-acetylaleuritolic acid, stigmasterol, a mixture of triterpenoids, fatty esters and aromatic components were isolated from the aerial parts of Eclipta prostrata by column chromatography. The plant extracts were investigated for their antimicrobial activity (agar dilution method) against twenty-eight strains of gram-positive and gram-negative bacteria, including diploid fungus. In addition, antioxidant and cytotoxic activities were also evaluated.The extracts and isolated fractions exhibited antimicrobial activity against Morexella catarrhalis, Corynebacterium diphtheriae NCTC 10356 and Streptococcus pyogenes with the MIC of 64 g/mL including Saccharomyces cerevisiae ATCC 2601 (MIC 256 g/mL). The ethyl acetate extract and isolated fractions displayed antioxidant effect. In addition, the plant extracts showed cytotoxic activity (ED50 > 100 g/mL) toward HuCCA-1 and KB cells. The results demonstrate beneficial effects of E. prostrata as the antimicrobials and bioactive compounds for medicinal usages.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/2119
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