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Title: Isolation and Structure Elucidation of a Novel Antimalarial Macrocyclic Polylactone, Menisporopsin A, from the Fungus Menisporopsis theobromae
Authors: Maneekarn Chinworrungsee
Prasat Kittakoop
Masahiko Isaka
Pacharee Maithip
Sumalee Supothina
Yodhathai Thebtaranonth
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Apr-2004
Citation: Journal of Natural Products. Vol.67, No.4 (2004), 689-692
Abstract: An antimalarial macrocyclic polylactone, menisporopsin A (1), was isolated from a cell extract of the seed fungus Menisporopsis theobromae. The structure of 1 was elucidated on the basis of spectroscopic analysis and chemical transformations, with the absolute configuration established by application of the modified Mosher method and by using chiral HPLC. Menisporopsin A (1) possesses an unprecedented residue, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl)benzoic acid. This compound exhibited antimalarial activity, with an IC50 value of 4.0 μg mL -1, and antimycobacterial activity (MIC value of 50 μg mL -1).
ISSN: 01633864
Appears in Collections:Scopus 2001-2005

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