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Title: Anti-HIV-1 cycloartanes from leaves and twigs of Gardenia thailandica
Authors: Patoomratana Tuchinda
Aroonchai Saiai
Manat Pohmakotr
Chalobon Yoosook
Jittra Kasisit
Chanita Napaswat
Thawatchai Santisuk
Vichai Reutrakul
Mahidol University
Thailand Royal Forest Department
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Apr-2004
Citation: Planta Medica. Vol.70, No.4 (2004), 366-370
Abstract: Thailandiol (1), gardenolic acid A (2), quadrangularic acid E (3) and 3β-hydroxy-5α-cycloart-24(31)-en-28-oic acid (4) have been isolated from the leaves and twigs of Gardenia thailandica Tirveng (order: Rubiales; family. Rubiaceae). In addition, 5-hydroxy-7,2′,3′, 4′5′6′-hexamethoxyflavone (5), 5,7-dihydroxy-2′, 3′, 4′,5′6′-pentamethoxyflavone (6), 5-hydroxy-7,2′,3′,4′,5′-pentamethoxyflavone (7) and 5,7-dihydroxy-2′,3′4′,5′-tetramethoxyflavone (8) were also isolated from the same source. The structures were elucidated by spectroscopic methods. Crude extracts and compounds 1-4 displayed anti-HIV-1 activities as determined by using theΔTat/RevMC99 virus and 1A2 cell line system. The EC50values determined by the syncytium assay ranged from < 7.8 to 110 μg/mL. They also exhibited moderate to high activities in reverse transcriptase (RT) assay; the IC50values of compounds 1-4, ranged from < 22.5 to 156.8 μg/mL.
ISSN: 00320943
Appears in Collections:Scopus 2001-2005

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