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dc.contributor.authorYaowared Sumanonten_US
dc.contributor.authorYukihisa Murakamien_US
dc.contributor.authorMichihisa Tohdaen_US
dc.contributor.authorOpa Vajraguptaen_US
dc.contributor.authorKinzo Matsumotoen_US
dc.contributor.authorHiroshi Watanabeen_US
dc.contributor.otherUniversity of Toyamaen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationBiological and Pharmaceutical Bulletin. Vol.27, No.2 (2004), 170-173en_US
dc.description.abstractCurcumin manganese complex (CpCpx) and diacetylcurcumin manganese complex (AcylCpCpx) were determined as to their effect on the nitric oxide (NO) radical scavenging in vitro method using a sodium nitroprusside generating NO system compared with their parent compound and astaxanthin, an extreme antioxidant. All compounds effectively reduced the generation of NO radicals in a dose dependent manner. They exhibited strong NO radical scavenging activity with low IC 50 values. The IC 50 values of curcumin, diacetylcurcumin, CpCpx and AcylCpCpx obtained are 20.39±4.10 μM, 28.76±1.48 μM, 9.79±1.50 μM and 8.09±0.99 μM, respectively. CpCpx and AcylCpCpx show greater NO radical scavenging than their parent compounds, curcumin and acetylcurcumin, respectively. However, the IC 50 values of curcumin and related compounds were found to be less than astaxanthin, an extreme antioxidant, with the lower IC 50 value of 3.42±0.50 μM. © 2004 Pharmaceutical Society of Japan.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleEvaluation of the nitric oxide radical scavenging activity of manganese complexes of curcumin and its derivativeen_US
Appears in Collections:Scopus 2001-2005

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