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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/21237
Title: Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies
Authors: Sriurai Thamprajamchit
Chanchai Jariengprasert
Rajata Rajatanavin
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-2004
Citation: Endocrine Practice. Vol.10, No.5 (2004), 432-437
Abstract: Objective: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Methods: We present the clinical findings, pertinent laboratory data, and follow-up course of a patient with Graves' disease and bilateral sensorineural hearing loss. We also provide a literature review regarding thionamideinduced ANCA-associated vasculitis. Results: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU. Audiograms showed bilateral sensorineural hearing loss with cochlear lesions. She also had low-grade fever, intermittent chronic abdominal pain, weight loss, polyarthralgia, and conjunctivitis. An indirect immunofluorescence test for ANCA was positive. The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment. Definitive therapy by subtotal thyroidectomy was subsequently performed and yielded good results. Conclusion: This rare case of PTU-induced ANCAassociated vasculitis manifested with ototoxicity in combination with systemic involvement. © 2004 AACE.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=17144398460&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/21237
ISSN: 1530891X
Appears in Collections:Scopus 2001-2005

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