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Title: Antimalarial and Antimicrobial Activities of 8-Aminoquinoline-Uracils Metal Complexes
Authors: Kamonrat Phopin
Nujarin Sinthupoom
Lertyot Treeratanapiboon
Sarun Kunwittaya
Supaluk Prachayasittikul
Somsak Ruchirawat
Virapong Prachayasittikul
Mahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technology
Keywords: Open Access article
Issue Date: Dec-2015
Citation: EXCLI Journal. Vol.15, 2016, 144-152
Abstract: 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.
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