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Title: Differential expression of interferon-γ and interferon-γ- inducing cytokines in Thai patients with scrub typhus or leptospirosis
Authors: Wirongrong Chierakul
Maaike De Fost
Yupin Suputtamongkol
Roongreung Limpaiboon
Arjen Dondorp
Nicholas J. White
Tom Van Der Poll
Mahidol University
University of Amsterdam
Udon Thani Rajabhat University
John Radcliffe Hospital
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Nov-2004
Citation: Clinical Immunology. Vol.113, No.2 (2004), 140-144
Abstract: Interferon (IFN)-γ plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-γ and IFN-γ-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-γ, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-α concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. © 2004 Elsevier Inc. All rights reserved.
ISSN: 15216616
Appears in Collections:Scopus 2001-2005

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