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dc.contributor.authorKamonrat Phopinen_US
dc.contributor.authorNujarin Sinthupoomen_US
dc.contributor.authorLertyot Treeratanapiboonen_US
dc.contributor.authorSarun Kunwittayaen_US
dc.contributor.authorSupaluk Prachayasittikul-
dc.contributor.authorSomsak Ruchirawat-
dc.contributor.authorVirapong Prachayasittikul-
dc.contributor.otherMahidol University. Faculty of Medical Technology. Department of Clinical Microbiology and Applied Technologyen_US
dc.identifier.citationEXCLI Journal. Vol.15, 2016, 144-152-
dc.description.abstract8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.en_US
dc.subjectOpen Access articleen_US
dc.titleAntimalarial and Antimicrobial Activities of 8-Aminoquinoline-Uracils Metal Complexesen_US
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