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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/21365
Title: Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices
Authors: Shunmay Yeung
Wirichada Pongtavornpinyo
Ian M. Hastings
Anne J. Mills
Nicholas J. White
Mahidol University
Liverpool School of Tropical Medicine
London School of Hygiene & Tropical Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-2004
Citation: American Journal of Tropical Medicine and Hygiene. Vol.71, No.2 SUPPL. (2004), 179-186
Abstract: Increasing resistance of Plasmodium falciparum malaria to antimalarial drugs is posing a major threat to the global effort to "Roll Back Malaria". Chloroquine and sulfadoxine-pyrimethamine (SP) are being rendered increasingly ineffective, resulting in increasing morbidity, mortality, and economic and social costs. One strategy advocated for delaying the development of resistance to the remaining armory of effective drugs is the wide-scale deployment of artemisinin-based combination therapy. However, the cost of these combinations are higher than most of the currently used monotherapies and alternative non-artemisinin-based combinations. In addition, uncertainty about the actual impact in real-life settings has made them a controversial choice for first-line treatment. The difficulties in measuring the burden of drug resistance and predicting the impact of strategies aimed at its reduction are outlined, and a mathematical model is introduced that is being designed to address these issues and to clarify policy options.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=4344696649&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/21365
ISSN: 00029637
Appears in Collections:Scopus 2001-2005

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