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Title: Immunoglobulin GM and KM genotypes in hepatitis C virus infection
Authors: Sasijit Vejbaesya
Taweesak Tanwandee
Janardan P. Pandey
Mahidol University
Medical University of South Carolina
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jul-2004
Citation: Journal of Medical Virology. Vol.73, No.3 (2004), 384-386
Abstract: Hepatitis C virus (HCV) is a major health problem, affecting over 170 million people worldwide. HCV causes a wide spectrum of liver disease, varying from persistent to asymptomatic infection. To evaluate the role of immunoglobulin (lg) GM and KM genes in HCV infection, 191 HCV-infected Thai subjects were studied. These included 43 individuals with transient HCV infection and 148 individuals with persistent chronic HCV infection. The controls consisted of 134 healthy individuals. Several GM and KM alleles were determined by polymerase chain reaction-based methods. The frequency of G1M(f) homozygotes was lower (52.4% vs. 64.2%, P= 0.03) and the frequency of G 1M(z) homozygotes was higher (10.5% vs. 3.7%, P= 0.02) in patients than the respective frequencies in controls. These results suggest that GM genotypes make a significant contribution to the risk of acquiring HCV infection. © 2004 Wiley-Liss, Inc.
ISSN: 01466615
Appears in Collections:Scopus 2001-2005

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