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Title: Genotype C of hepatitis B virus can be classified into at least two subgroups
Authors: Tran Thien Tuan Huy
Hiroshi Ushijima
Vo Xuan Quang
Khin Maung Win
Pairoj Leungrojanakul
Kaoru Kikuchi
Tetsutaro Sata
Kenji Abe
National Institute of Infectious Diseases
University of Tokyo
Cho Ray Hospital
Yangon General Hospital
Mahidol University
Okinawa Chubu Hospital
Keywords: Immunology and Microbiology
Issue Date: 1-Feb-2004
Citation: Journal of General Virology. Vol.85, No.2 (2004), 283-292
Abstract: A genomic characterization of hepatitis B virus (HBV) was done for 56 pre-S1/pre-S2 genes and 10 full-length HBV genotype C isolates from five Asian countries. Phylogenetic analysis of the pre-S1/pre-S2 genes revealed two major groups within genotype C: one for isolates from southeast Asia including Vietnam, Myanmar and Thailand (named HBV/C1) and the other for isolates from Far East Asia including Japan, Korea and China (named HBV/C2). This finding was confirmed by phylogenetic analysis based on the full-length sequence of 32 HBV genotype C isolates, including 22 from database entries. Two isolates from Okinawa, the island off the southern end of Japan, formed a different branch. Specific amino acid sequence changes were identified in the large S protein (amino acids 51, 54, 60, 62 and 73) and P protein (amino acids 231, 233, 236, 248, 252 and 304). Our results indicate that genotype C of HBV can be classified into at least two subgroups. © 2004 SGM.
ISSN: 00221317
Appears in Collections:Scopus 2001-2005

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