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dc.contributor.authorTran Thien Tuan Huyen_US
dc.contributor.authorHiroshi Ushijimaen_US
dc.contributor.authorVo Xuan Quangen_US
dc.contributor.authorKhin Maung Winen_US
dc.contributor.authorPairoj Leungrojanakulen_US
dc.contributor.authorKaoru Kikuchien_US
dc.contributor.authorTetsutaro Sataen_US
dc.contributor.authorKenji Abeen_US
dc.contributor.otherNational Institute of Infectious Diseasesen_US
dc.contributor.otherUniversity of Tokyoen_US
dc.contributor.otherCho Ray Hospitalen_US
dc.contributor.otherYangon General Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherOkinawa Chubu Hospitalen_US
dc.identifier.citationJournal of General Virology. Vol.85, No.2 (2004), 283-292en_US
dc.description.abstractA genomic characterization of hepatitis B virus (HBV) was done for 56 pre-S1/pre-S2 genes and 10 full-length HBV genotype C isolates from five Asian countries. Phylogenetic analysis of the pre-S1/pre-S2 genes revealed two major groups within genotype C: one for isolates from southeast Asia including Vietnam, Myanmar and Thailand (named HBV/C1) and the other for isolates from Far East Asia including Japan, Korea and China (named HBV/C2). This finding was confirmed by phylogenetic analysis based on the full-length sequence of 32 HBV genotype C isolates, including 22 from database entries. Two isolates from Okinawa, the island off the southern end of Japan, formed a different branch. Specific amino acid sequence changes were identified in the large S protein (amino acids 51, 54, 60, 62 and 73) and P protein (amino acids 231, 233, 236, 248, 252 and 304). Our results indicate that genotype C of HBV can be classified into at least two subgroups. © 2004 SGM.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleGenotype C of hepatitis B virus can be classified into at least two subgroupsen_US
Appears in Collections:Scopus 2001-2005

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