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Title: The Deformability of Red Blood Cells Parasitized by Plasmodium falciparum and P. vivax
Authors: Rossarin Suwanarusk
Brian M. Cooke
Arjen M. Dondorp
Kamolrat Silamut
Jetsumon Sattabongkot
Nicholas J. White
Rachanee Udomsangpetch
Faculty of Medical Technology
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Monash University
Nuffield Department of Clinical Medicine
Keywords: Immunology and Microbiology;Medicine
Issue Date: 15-Jan-2004
Citation: Journal of Infectious Diseases. Vol.189, No.2 (2004), 190-194
Abstract: Red blood cells (RBCs) must deform considerably during their multiple passages through the microvasculature and the sinusoids of the spleen. RBCs infected with Plasmodium falciparum (Pf-IRBCs) become increasingly rigid as they mature but avoid splenic clearance by sequestering in venules and capillaries. In contrast, RBCs infected with P. vivax (Pv-IRBCs) do not sequester. We compared the effects of P. vivax and P. falciparum infection on RBC deformability in a laminar shear flow system. Pf-IRBCs became more rigid as the parasite matured, but equivalent maturation of Pv-IRBCs resulted in a doubling of flexibility. Coincidentally, the IRBC surface area increased from 56.7 ± 1.3 μm2to 74.7 ± 0.6 μm2to 90.9 ±1.1 μm2in ring-, trophozoite-, and schizont-stage Pv-IRBCs, respectively, whereas Pf-IRBCs did not increase in size. P. vivax increases the deformability of IRBCs and thereby avoids splenic entrapment.
ISSN: 00221899
Appears in Collections:Scopus 2001-2005

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