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|Title:||The Deformability of Red Blood Cells Parasitized by Plasmodium falciparum and P. vivax|
Brian M. Cooke
Arjen M. Dondorp
Nicholas J. White
Faculty of Medical Technology
Armed Forces Research Institute of Medical Sciences, Thailand
Nuffield Department of Clinical Medicine
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||Journal of Infectious Diseases. Vol.189, No.2 (2004), 190-194|
|Abstract:||Red blood cells (RBCs) must deform considerably during their multiple passages through the microvasculature and the sinusoids of the spleen. RBCs infected with Plasmodium falciparum (Pf-IRBCs) become increasingly rigid as they mature but avoid splenic clearance by sequestering in venules and capillaries. In contrast, RBCs infected with P. vivax (Pv-IRBCs) do not sequester. We compared the effects of P. vivax and P. falciparum infection on RBC deformability in a laminar shear flow system. Pf-IRBCs became more rigid as the parasite matured, but equivalent maturation of Pv-IRBCs resulted in a doubling of flexibility. Coincidentally, the IRBC surface area increased from 56.7 ± 1.3 μm2to 74.7 ± 0.6 μm2to 90.9 ±1.1 μm2in ring-, trophozoite-, and schizont-stage Pv-IRBCs, respectively, whereas Pf-IRBCs did not increase in size. P. vivax increases the deformability of IRBCs and thereby avoids splenic entrapment.|
|Appears in Collections:||Scopus 2001-2005|
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