Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/21479
Title: Gastrointestinal lymphoma in Thailand: A clinicopathologic analysis of 120 cases at Siriraj Hospital according to who classification
Authors: Sanya Sukpanichnant
Chirayu Udomsakdi-Auewarakul
Theera Ruchutrakool
Somchai Leelakusolvong
Somprak Boonpongmanee
Vitoon Chinswangwatanakul
Mahidol University
Tri‐Cities Cancer Center
Keywords: Medicine
Issue Date: 1-Dec-2004
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.35, No.4 (2004), 966-976
Abstract: Clinicopathologic information of gastrointestinal (GI) lymphoma in Southeast Asia is lacking. A retrospective analysis of 120 cases of GI lymphoma in Thailand diagnosed at Siriraj Hospital based on WHO classification was performed. All were non-Hodgkin lymphoma (NHL). The peak age was in the sixth and seventh decades; a slight male preponderance was observed. Sites of involvement included stomach (49.2%), intestine (46.7%), and multiple sites (4.2%). There were 104 cases of primary GI lymphoma (86.7%) and 16 cases of secondary GI lymphoma (13.3%). Presenting GI symptoms were more common in the former; while superficial lymphadenopathy and fever were more common in the latter. Mass lesions were observed in both groups (72.1% vs 56.3%). Localized and advanced diseases were found in 68.3% and 31.7% of primary GI lymphomas, respectively. The most common type of lymphoma in both groups was diffuse large B-cell lymphoma. Lymphoepithelial lesions (LEL) were not significantly different between the two groups (58.2% vs 42.9%), but Helicobacter pylori infection was significantly associated with primary gastric lymphoma (p<0.0001). The treatment of choice for localized primary GI lymphoma is controversial. Complete surgical resection may increase the chance of complete remission, but mortality and relapse rates might be higher than those observed with combination chemotherapy alone. GI lymphomas in Thailand are mostly primary B-cell NHL. LEL is not indicative of primary GI lymphoma, but H. pylori infection is closely associated with primary gastric lymphoma. A prospective study to determine the treatment of choice for localized GI lymphoma is needed.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=12444344999&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/21479
ISSN: 01251562
Appears in Collections:Scopus 2001-2005

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.