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Title: Evaluation of immunoglobulin M (IgM) and IgG rapid cassette test kits for diagnosis of melioidosis in an area of endemicity
Authors: Vanaporn Wuthiekanun
Premjit Amornchai
Wirongrong Chierakul
Allen C. Cheng
Nicholas J. White
Sharon J. Peacock
Nicholas P.J. Day
Mahidol University
Flinders University
Nuffield Department of Clinical Medicine
Keywords: Medicine
Issue Date: 1-Aug-2004
Citation: Journal of Clinical Microbiology. Vol.42, No.8 (2004), 3435-3437
Abstract: An enzyme-linked immunosorbent assay-based rapid cassette immunoglobulin G (IgG) and IgM immunochromogenic test kit was compared to the indirect hemagglutination test (IHA) for the diagnosis of acute melioidosis in northeastern Thailand. Admission sera from 70 culture-confirmed septicemic melioidosis patients and 30 patients with localized infections were tested. As a control group, 80 patients with other acute febrile illnesses (other bacterial infections, leptospirosis, or scrub typhus) and 119 healthy individuals were tested. The diagnostic sensitivity of the IgG and IgM tests and the IHA test were 79, 67, and 72%, respectively, with corresponding specificities of 90, 80, and 68%. This kit represents an improvement over IHA for the diagnosis of melioidosis an area of endemicity although, as with other serological tests, it has reduced diagnostic utility in a population with high background seropositivity.
ISSN: 00951137
Appears in Collections:Scopus 2001-2005

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