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|Title:||No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells|
|Citation:||Journal of the Medical Association of Thailand. Vol.87, No.7 (2004), 816-818|
|Abstract:||Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.|
|Appears in Collections:||Scopus 2001-2005|
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