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Title: No expression of human leukocyte antigen G (HLA-G) in colorectal cancer cells
Authors: Kawin Leelawat
Surang Engprasert
Urai Pongchai-Rerk
Supatip Tuchinda
Cheepsumon Suthipintawong
Vijittra Leardkamolkarn
Mahidol University
Rajavithi Hospital
Kyushu University
Keywords: Medicine
Issue Date: 1-Jul-2004
Citation: Journal of the Medical Association of Thailand. Vol.87, No.7 (2004), 816-818
Abstract: Although there is a specific antitumor immune response in the body, colorectal cancer cells progressively develop. This fact indicated that the cancer cells could have a variety of mechanisms to evade or escape the immune system. HLA-G is identified to inhibit the recognition of NK-cell in various kinds of cancers. This study investigated the expression of HLA-G in colorectal cancer. Eighty five specimens of colorectal cancer, carcinoma in situ and adenomatous polyp were examined by immunohistochemistry and RT-PCR for the detection of human leukocyte antigen (HLA)-G The expression of HLA-G was not found in all colorectal specimens (85/85) both protein level and transcription level, suggesting that the expression of HLA-G is not a possible immune evasion mechanism of colorectal cancer cell.
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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