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Title: Comparison of artesunate and chloroquine activities against Plasmodium vivax gametocytes
Authors: Mathieu Nacher
Udomsak Silachamroon
Pratap Singhasivanon
Polrat Wilairatana
Weerapong Phumratanaprapin
Arnaud Fontanet
Sornchai Looareesuwan
Mahidol University
Shoklo Malaria Research Unit
Institut Pasteur, Paris
Centre Hospitalier Andree Rosemon
Keywords: Medicine
Issue Date: 1-Jul-2004
Citation: Antimicrobial Agents and Chemotherapy. Vol.48, No.7 (2004), 2751-2752
Abstract: The gametocidal activities of chloroquine and artesunate were compared. The relative risk (RR) of having detectable gametocytes appear after treatment initiation was lower in artesunate-treated patients (n = 792) than in chloroquine-treated patients (n = 695) (RR = 0.29; 95% CI = 0.2 to 0.40; P < 0.0001). The duration and magnitude of gametocyte carriage were also lower for artesunate than chloroquine. By reducing the transmission of Plasmodium vivax to the vector, artesunate could therefore reduce the incidence of P. vivax malaria.
ISSN: 00664804
Appears in Collections:Scopus 2001-2005

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