Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/21642
Title: Mycobacterial skin infections: Comparison between histopathologic features and detection of acid fast bacilli in pathologic section
Authors: Punkae Mahaisavariya
Jane Manonukul
Supakan Khemngern
Angkana Chaiprasert
Mahidol University
Keywords: Medicine
Issue Date: 1-Jun-2004
Citation: Journal of the Medical Association of Thailand. Vol.87, No.6 (2004), 709-712
Abstract: Background: Detection of acid fast bacilli (AFB) in chronic granulomatous inflammation is an important clue for mycobacterial infection. Design: A retrospective review of 104 pathologic sections (from 1994 to 2001) of suspected cases of mycobacterial (tuberculous and nontuberculous) skin infections to study histopathologic features and the correlation with the presence of AFB in the section was performed. Results: All cases showed granulomatous inflammations that can be categorized into 4 types: mixed cell, suppurative, tuberculoid and palisading granuloma. AFB was found in 32 sections (30.77%). Ninety five specimens from 104 specimens were simultaneously cultured. AFB positive cases yielded higher positive cultural results, 17 from 29 cases (58.62%) compared to the AFB negative group, 23 from 66 cases, (34.85%). Mixed cell granuloma was the most common histologic feature, but suppurative granuloma was the most common histological feature (56.25%) in which AFB could be found, which was statistically significantly different from other types of granuloma. Tuberculoid granuloma was more common in the AFB negative group (20.83%) compared to the AFB positive group (9.37%) but the difference was not statistically significant. In cases that AFB could not be found, the inflammation tended to be located in the upper half of the dermis. Conclusion: AFB can be more frequently detected in suppurative granuloma that might be located in any portion of the dermis. This finding was not species specific.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=3543141729&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/21642
ISSN: 01252208
Appears in Collections:Scopus 2001-2005

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