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|Title:||Red blood cell vesicles in thalassemia|
|Citation:||Journal of the Medical Association of Thailand. Vol.87, No.3 (2004), 233-238|
|Abstract:||Vesicles are part of the red blood cells membrane which can be found in a small number in normal apoptotic process and increased in some diseases. In the present study, the authors measured the percentage of red blood cell vesicles in healthy subjects (n = 7), patients with α-thalassemia or Hemoglobin (Hb) H disease (n = 7), β-thal/Hb E with nonsplenectomized (n = 5) and splenectomized (n = 7) before and after induction heated at 48.6°C by using flow cytometry. It was found that the percentage of vesicles in every group were not statistically significantly different (p > 0.05) between pre and post incubation at 5 min. The percentage of vesicles of healthy subjects, β-thal/Hb E nonsplenectomized patients and splenectomized patients were highest when induced by heating for 60 min. For patients with Hb H disease, the percentage of vesicles was maximum at 30 min when compared with healthy subjects, β-thal/Hb E nonsplenectomized patients and splenectomized patients, respectively. In the present study, the authors report the significant increase of the percentage of vesicles in Hb H disease, β-thal/Hb E nonsplenectomized and splene'ctomized after induction by heat when compared with healthy subjects. These findings may support the different pathology of the red blood cells found in α- and β-thalassemia.|
|Appears in Collections:||Scopus 2001-2005|
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