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Title: Effect of a dietary n-6 polyunsaturated fatty acid supplement on distinct immune functions of goats
Authors: J. Thanasak
V. P M G Rutten
J. T H Schonewille
A. Hoek
A. C. Beynen
J. P T M Noordhuizen
K. E. Müller
Utrecht University
Mahidol University
Freie Universitat Berlin
Keywords: Medicine;Veterinary
Issue Date: 1-Feb-2004
Citation: Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine. Vol.51, No.1 (2004), 1-9
Abstract: The aim of this study was to investigate whether dietary n-6 polyunsaturated fatty acids (PUFA) alter immune functions as lymphocyte blastogenesis, expression of lymphocyte and monocyte markers, and cell adhesion molecules of the integrin family in goats. Dutch White castrated male goats received a diet either rich in olive oil (control group, n = 4) or rich in corn oil (test group, n = 4) over a period of 3 weeks. The animals in the test group had significantly higher linoleic acid (LA, 18:2n-6) levels in plasma on days 7, 14 and 21 of the diet than control animals. This was also true for washed erythrocyte membranes at day 21. A significant reduction in the percentage of α-4 integrin (CD49d) expressing lymphocytes was observed in goats fed LA rich corn oil at day 21. However, no changes were observed in either lymphocyte proliferative responses to ConA and PHA or the expression of other lymphocyte/monocyte markers. In conclusion, feeding corn oil rich in LA caused significant increases in the proportion of LA in the fatty acid composition of plasma and erythrocyte membranes and was accompanied by a significant decrease of the adhesion molecule α-4 integrin (CD49d) on lymphocytes but not on monocytes. © 2004 Blackwell Verlag, Berlin.
ISSN: 0931184X
Appears in Collections:Scopus 2001-2005

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